Indicated for Colic-like pain, Cramps, Minor stiffness in joints. Colocynthis is a homeopathic remedy commonly used for colics and cramping that is severe causing the patient to bend double and/or press something hard against the abdomen. It is also used at times for diarrhea and for sciatic pain that is crampy in nature. The patient is often worse from anger and indignation. This homeopathic remedy is made from a plant known as bitter cucumber. Active ingredient: Colocynthis [HPUS]. Inactive ingredients: Sucrose/lactose pellets.